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FGFRL1 Antibody (PACO16345)

SKU:
PACO16345
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
  • FGFRL1 Antibody PACO16345
  • FGFRL1 Antibody PACO16345
$407
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Description

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FGFRL1 Antibody (PACO16345)

The FGFR-Like 1 (FGFRL1) Polyclonal Antibody (PAC016345) is a valuable tool for researchers studying the role of FGFRL1 in various cellular processes. FGFRL1 is a member of the fibroblast growth factor receptor (FGFR) family, and is known to regulate cell proliferation, differentiation, and survival.This antibody, raised in rabbits, is highly specific to human samples and is validated for use in Western blot applications. It binds specifically to the FGFRL1 protein, allowing for accurate detection and analysis in a variety of cell types.

This makes it an ideal choice for studies in developmental biology, cancer research, and other fields where FGFRL1 function is under investigation.Understanding the role of FGFRL1 is essential for furthering our knowledge of cellular signaling pathways and may have implications for the development of targeted therapies for diseases such as cancer. The FGFRL1 Polyclonal Antibody is a valuable tool for researchers looking to explore the functions of this important protein in health and disease.

Antibody Name:FGFRL1 Antibody (PACO16345)
Antibody SKU:PACO16345
Size:50ul
Host Species:Rabbit
Tested Applications:ELISA, IHC
Recommended Dilutions:ELISA:1:1000-1:2000, IHC:1:25-1:100
Species Reactivity:Human, Mouse, Rat
Immunogen:Fusion protein of human FGFRL1
Form:Liquid
Storage Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:Antigen affinity purification
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageThe image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO16345(FGFRL1 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200).
Product ImageThe image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO16345(FGFRL1 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200).
Background:The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid, sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. A marked difference between this gene product and the other family members is its lack of a cytoplasmic tyrosine kinase domain. The result is a transmembrane receptor that could interact with other family members and potentially inhibit signaling. Multiple alternatively spliced transcript variants encoding the same isoform have been found for this gene.
Synonyms:fibroblast growth factor receptor-like 1
UniProt Protein Function:FGFRL1: Has a negative effect on cell proliferation.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 4p16Cellular Component: Golgi apparatus; plasma membrane; transport vesicleMolecular Function: fibroblast growth factor receptor activity; heparin bindingBiological Process: fibroblast growth factor receptor signaling pathway; protein heterooligomerization; protein homooligomerizationDisease: Wolf-hirschhorn Syndrome
UniProt Protein Details:
NCBI Summary:The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. A marked difference between this gene product and the other family members is its lack of a cytoplasmic tyrosine kinase domain. The result is a transmembrane receptor that could interact with other family members and potentially inhibit signaling. Multiple alternatively spliced transcript variants encoding the same isoform have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:Q8N441
NCBI GenInfo Identifier:68052359
NCBI Gene ID:53834
NCBI Accession:Q8N441.1
UniProt Secondary Accession:Q8N441,Q6PJN1, Q9BXN7, Q9H4D7, B2RAU9
UniProt Related Accession:Q8N441
Molecular Weight:54,537 Da
NCBI Full Name:Fibroblast growth factor receptor-like 1
NCBI Synonym Full Names:fibroblast growth factor receptor-like 1
NCBI Official Symbol:FGFRL1  
NCBI Official Synonym Symbols:FHFR; FGFR5  
NCBI Protein Information:fibroblast growth factor receptor-like 1
UniProt Protein Name:Fibroblast growth factor receptor-like 1
UniProt Synonym Protein Names:FGF homologous factor receptor; FGFR-like protein; Fibroblast growth factor receptor 5; FGFR-5
Protein Family:Fibroblast growth factor receptor
UniProt Gene Name:FGFRL1  
UniProt Entry Name:FGRL1_HUMAN
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