FGFRL1 Antibody (PACO16344)
- SKU:
- PACO16344
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
FGFRL1 Antibody (PACO16344)
The FGFR-Like Protein 1 (FGFRL1) Polyclonal Antibody (PAC016344) is a valuable tool for researchers studying the function of FGFRL1, a member of the fibroblast growth factor receptor (FGFR) family. This antibody, generated in rabbits, is highly specific and reactive with human samples, making it suitable for Western blot applications. By binding to the FGFRL1 protein, this antibody enables accurate detection and analysis in various cell types, making it an essential tool for studies in developmental biology, cancer research, and other areas where FGFRL1 is implicated.
FGFRL1, also known as FGFR5, is a unique member of the FGFR family with distinct functions in cell signaling and development. It has been shown to play a role in various processes, such as cell proliferation, differentiation, and migration. Research has also suggested a potential involvement of FGFRL1 in cancer progression, making it a promising target for therapeutic interventions. By investigating the function and regulation of FGFRL1, researchers can gain valuable insights into its role in health and disease, paving the way for novel treatment strategies.
| Antibody Name: | FGFRL1 Antibody (PACO16344) |
| Antibody SKU: | PACO16344 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:200-1:1000, IHC:1:100-1:300 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Fusion protein of human FGFRL1 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO16344(FGFRL1 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200). |
 | Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-3: NIH/3T3 cells, human placenta tissue, lovo cells, Primary antibody: PACO16344(FGFRL1 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute. |
 | The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO16344(FGFRL1 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200). |
| Background: | The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid, sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. A marked difference between this gene product and the other family members is its lack of a cytoplasmic tyrosine kinase domain. The result is a transmembrane receptor that could interact with other family members and potentially inhibit signaling. Multiple alternatively spliced transcript variants encoding the same isoform have been found for this gene. |
| Synonyms: | fibroblast growth factor receptor-like 1 |
| UniProt Protein Function: | FGFRL1: Has a negative effect on cell proliferation.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 4p16Cellular Component: Golgi apparatus; plasma membrane; transport vesicleMolecular Function: fibroblast growth factor receptor activity; heparin bindingBiological Process: fibroblast growth factor receptor signaling pathway; protein heterooligomerization; protein homooligomerizationDisease: Wolf-hirschhorn Syndrome |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. A marked difference between this gene product and the other family members is its lack of a cytoplasmic tyrosine kinase domain. The result is a transmembrane receptor that could interact with other family members and potentially inhibit signaling. Multiple alternatively spliced transcript variants encoding the same isoform have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q8N441 |
| NCBI GenInfo Identifier: | 68052359 |
| NCBI Gene ID: | 53834 |
| NCBI Accession: | Q8N441.1 |
| UniProt Secondary Accession: | Q8N441,Q6PJN1, Q9BXN7, Q9H4D7, B2RAU9 |
| UniProt Related Accession: | Q8N441 |
| Molecular Weight: | 54,537 Da |
| NCBI Full Name: | Fibroblast growth factor receptor-like 1 |
| NCBI Synonym Full Names: | fibroblast growth factor receptor-like 1 |
| NCBI Official Symbol: | FGFRL1Â Â |
| NCBI Official Synonym Symbols: | FHFR; FGFR5Â Â |
| NCBI Protein Information: | fibroblast growth factor receptor-like 1 |
| UniProt Protein Name: | Fibroblast growth factor receptor-like 1 |
| UniProt Synonym Protein Names: | FGF homologous factor receptor; FGFR-like protein; Fibroblast growth factor receptor 5; FGFR-5 |
| Protein Family: | Fibroblast growth factor receptor |
| UniProt Gene Name: | FGFRL1Â Â |
| UniProt Entry Name: | FGRL1_HUMAN |
| Antibodies |
| FGFRL1 Antibody (PACO02979) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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