The FGFR-Like Protein 1 (FGFRL1) Antibody (PAC002979) is a key tool for researchers studying the functions of FGFRL1 in various cellular processes. FGFRL1 is a member of the fibroblast growth factor receptor (FGFR) family and is involved in regulating cell growth, differentiation, and survival. This polyclonal antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications.By targeting the FGFRL1 protein, this antibody allows for the detection and analysis of FGFRL1 expression levels in different cell types, providing valuable insights for studies in molecular biology and cancer research.
With its ability to identify FGFRL1 in cell signaling pathways, this antibody is instrumental in understanding the role of FGFRL1 in normal cellular function and disease progression.Given the potential implications of FGFRL1 in cancer development and progression, this antibody is indispensable for researchers investigating the molecular mechanisms underlying tumorigenesis and the identification of novel therapeutic targets. Its specificity and reliability make it a valuable tool for advancing our understanding of FGFRL1 biology and its relevance in disease pathology.
Antibody Name:
FGFRL1 Antibody
Antibody SKU:
PACO02979
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
WB:1:500-1:2000
Species Reactivity:
Human, Mouse
Immunogen:
synthesized peptide derived from the Internal region of human FGFR-5.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
FGFRL1: Has a negative effect on cell proliferation.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 4p16Cellular Component: Golgi apparatus; plasma membrane; transport vesicleMolecular Function: fibroblast growth factor receptor activity; heparin bindingBiological Process: fibroblast growth factor receptor signaling pathway; protein heterooligomerization; protein homooligomerizationDisease: Wolf-hirschhorn Syndrome
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. A marked difference between this gene product and the other family members is its lack of a cytoplasmic tyrosine kinase domain. The result is a transmembrane receptor that could interact with other family members and potentially inhibit signaling. Multiple alternatively spliced transcript variants encoding the same isoform have been found for this gene. [provided by RefSeq, Jul 2008]
