The FGFR4 Rabbit Monoclonal Antibody (CAB9197) is a vital tool for researchers studying the Fibroblast Growth Factor Receptor 4 (FGFR4) protein, which plays a crucial role in cell proliferation, differentiation, and survival. This antibody, raised in rabbits, offers high specificity and sensitivity in detecting FGFR4 in human samples, making it ideal for use in various research applications such as Western blotting.FGFR4 is a member of the FGFR family, known for its involvement in signal transduction pathways that regulate cell growth and development. Dysregulation of FGFR4 signaling has been linked to various diseases, including cancer, making it a promising target for therapeutic interventions.
By utilizing the FGFR4 Rabbit Monoclonal Antibody, researchers can analyze FGFR4 expression and activity in different cell types, shedding light on its role in disease pathogenesis and potential treatment strategies.Overall, the FGFR4 Rabbit Monoclonal Antibody (CAB9197) is a valuable tool for investigators seeking to delve deeper into the molecular mechanisms governed by FGFR4, ultimately paving the way for innovative research breakthroughs in areas such as cancer biology and targeted therapy development.
Product Name:
FGFR4 Rabbit Monoclonal Antibody
SKU:
CAB9197
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 700-802 of human FGFR4 (P22455).
Cell membrane, Cytoplasm, Endoplasmic reticulum, Endosome, Secreted, Single-pass type I membrane protein.
Calculated MW:
88kDa
Observed MW:
95kDa/125kDa
The protein encoded by this gene is a tyrosine kinase and cell surface receptor for fibroblast growth factors. The encoded protein is involved in the regulation of several pathways, including cell proliferation, cell differentiation, cell migration, lipid metabolism, bile acid biosynthesis, vitamin D metabolism, glucose uptake, and phosphate homeostasis. This protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment, and a cytoplasmic tyrosine kinase domain. The extracellular portion interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation.
Purification Method:
Affinity purification
Gene ID:
2264
Clone Number:
ARC1474
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using FGFR4 Rabbit mAb (CAB9197) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3min.
