The FGFR4 Polyclonal Antibody (CAB7555) is a valuable tool for researchers studying fibroblast growth factor receptor 4 (FGFR4), a key player in cell growth and differentiation processes. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications.By binding to the FGFR4 protein, this antibody allows for accurate detection and analysis in various cell types, making it an ideal choice for studies in cancer biology, developmental biology, and regenerative medicine.
FGFR4 is known to play a crucial role in cell proliferation, survival, and migration, and dysregulation of FGFR4 signaling has been implicated in various cancers and other diseases.Understanding the function and regulation of FGFR4 is essential for developing targeted therapies and personalized medicine approaches in the treatment of cancer and other related conditions. The FGFR4 Polyclonal Antibody (CAB7555) provides researchers with a reliable tool to explore the role of FGFR4 in health and disease.
Product Name:
FGFR4 Rabbit Polyclonal Antibody
SKU:
CAB7555
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 22-150 of human FGFR4 (NP_998812.1).
Cell membrane, Cytoplasm, Endoplasmic reticulum, Endosome, Secreted, Single-pass type I membrane protein.
Calculated MW:
88kDa
Observed MW:
110kDa
The protein encoded by this gene is a tyrosine kinase and cell surface receptor for fibroblast growth factors. The encoded protein is involved in the regulation of several pathways, including cell proliferation, cell differentiation, cell migration, lipid metabolism, bile acid biosynthesis, vitamin D metabolism, glucose uptake, and phosphate homeostasis. This protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment, and a cytoplasmic tyrosine kinase domain. The extracellular portion interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation.
Purification Method:
Affinity purification
Gene ID:
2264
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using FGFR4 antibody (CAB7555) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
