The FGFR3 Rabbit Monoclonal Antibody (CAB19052) is a valuable tool for researchers studying the FGFR3 protein, a receptor tyrosine kinase involved in cell growth and differentiation. This antibody, produced in rabbits, exhibits high specificity and sensitivity for detecting FGFR3 in human samples, making it an ideal choice for Western blot applications.FGFR3 plays a crucial role in various biological processes, including skeletal development, bone formation, and cell proliferation. Dysregulation of FGFR3 has been linked to cancer and skeletal disorders, making it a significant target for therapeutic interventions.
By utilizing the FGFR3 Rabbit Monoclonal Antibody, researchers can accurately detect and analyze FGFR3 expression in different cell types, leading to a better understanding of its function in both normal physiology and disease pathology.With its reliable performance and broad applicability in immunology and cancer research, the FGFR3 Rabbit Monoclonal Antibody (CAB19052) is a valuable asset for investigations aimed at uncovering the role of FGFR3 in various cellular processes and disease states.
Product Name:
FGFR3 Rabbit Monoclonal Antibody
SKU:
CAB19052
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human FGFR3 (P22607).
Cell membrane, Cytoplasmic vesicle, Endoplasmic reticulum, Secreted, Single-pass type I membrane protein.
Calculated MW:
88kDa
Observed MW:
110kDa
This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia.
Purification Method:
Affinity purification
Gene ID:
2261
Clone Number:
ARC0398
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using FGFR3 Rabbit mAb (CAB19052) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3min.
