FGFR3 Rabbit Monoclonal Antibody (CAB19052)
- SKU:
- CAB19052
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Death
Description
Product Name: | FGFR3 Rabbit Monoclonal Antibody |
SKU: | CAB19052 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human FGFR3 (P22607). |
Sequence: | MGAP ACAL ALCV AVAI VAGA SSES LGTE QRVV GRAA EVPG PEPG QQEQ LVFG SGDA VELS CPPP GGGP MGPT VWVK DGTG LVPS ERVL VGPQ RLQV LNAS |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:1000 - 1:5000 |
Synonyms: | ACH; CEK2; JTK4; CD333; HSFGFR3EX; FGFR3 |
Positive Sample: | 293T,Mouse brain,Mouse lung,Rat lung,Rat kidney |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Cytoplasmic vesicle, Endoplasmic reticulum, Secreted, Single-pass type I membrane protein. |
Calculated MW: | 88kDa |
Observed MW: | 110kDa |
This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia.
Purification Method: | Affinity purification |
Gene ID: | 2261 |
Clone Number: | ARC0398 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |