The FGFR3 Polyclonal Antibody is a valuable tool for researchers studying FGFR3, a member of the fibroblast growth factor receptor family involved in cell growth and differentiation. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding to the FGFR3 protein, researchers can easily detect and analyze its expression in various cell types, making it an excellent choice for studies in developmental biology and cancer research.FGFR3 plays a crucial role in cell signaling pathways that govern cell proliferation, differentiation, and survival.
Dysregulation of FGFR3 activity has been implicated in various diseases, including skeletal disorders and cancers. By studying the functions of FGFR3, researchers can gain insights into the molecular mechanisms underlying these diseases and identify potential therapeutic targets.Overall, the FGFR3 Polyclonal Antibody is a reliable tool for investigating the functions of FGFR3 in cellular processes and disease pathogenesis. Its specificity and sensitivity make it an essential component of any research project aimed at unraveling the complexities of FGFR3 biology.
Product Name:
FGFR3 Polyclonal Antibody
SKU:
CAB24846
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 23-375 of human FGFR3(NP_000133.1).
Cell membrane, Cytoplasmic vesicle, Endoplasmic reticulum, Secreted, Single-pass type I membrane protein.
Calculated MW:
75kDa/85kDa/87kDa/88kDa
Observed MW:
100-150kDa
This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described.
Purification Method:
Affinity purification
Gene ID:
2261
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from K-562 cells using [KD Validated] FGFR3 Rabbit pAb(CAB24846) at 1:400 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25 μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
