The FGFR3 Polyclonal Antibody (CAB0404) is a valuable tool for researchers studying FGFR3, a receptor tyrosine kinase known for its role in cell growth and differentiation. This antibody, generated in rabbits, is highly specific for human samples and has been validated for use in Western blot applications.FGFR3 is a key player in various cellular processes, including development, tissue repair, and angiogenesis. Dysregulation of FGFR3 signaling has been linked to a range of diseases, including skeletal disorders, cancer, and developmental abnormalities. By targeting FGFR3 with this antibody, researchers can investigate its expression and activity in different cell types, shedding light on its function in both normal and disease states.
With its high reactivity and specificity, the FGFR3 Polyclonal Antibody is an essential tool for researchers conducting studies in cell biology, cancer research, and developmental biology. By enabling accurate detection and analysis of FGFR3 protein levels, this antibody opens new avenues for understanding the molecular mechanisms underlying various diseases and identifying potential therapeutic targets.
Product Name:
FGFR3 Rabbit Polyclonal Antibody
SKU:
CAB0404
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 700-806 of human FGFR3 (NP_000133.1).
Cell membrane, Cytoplasmic vesicle, Endoplasmic reticulum, Secreted, Single-pass type I membrane protein.
Calculated MW:
88kDa
Observed MW:
125kDa
This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia.
Purification Method:
Affinity purification
Gene ID:
2261
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of Rat brain, using FGFR3 antibody (CAB0404) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
