FGFR3 Rabbit Polyclonal Antibody (CAB0404)
- SKU:
- CAB0404
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Description
Product Name: | FGFR3 Rabbit Polyclonal Antibody |
SKU: | CAB0404 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 700-806 of human FGFR3 (NP_000133.1). |
Sequence: | VEEL FKLL KEGH RMDK PANC THDL YMIM RECW HAAP SQRP TFKQ LVED LDRV LTVT STDE YLDL SAPF EQYS PGGQ DTPS SSSS GDDS VFAH DLLP PAPP SSGG SRT |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:100 IF/ICC,1:50 - 1:200 |
Synonyms: | ACH; CEK2; JTK4; CD333; HSFGFR3EX; FGFR3 |
Positive Sample: | Rat brain |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Cytoplasmic vesicle, Endoplasmic reticulum, Secreted, Single-pass type I membrane protein. |
Calculated MW: | 88kDa |
Observed MW: | 125kDa |
This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia.
Purification Method: | Affinity purification |
Gene ID: | 2261 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |