Description
Product Name: | FGFR3 Polyclonal Antibody |
SKU: | CAB24846 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 23-375 of human FGFR3(NP_000133.1). |
Sequence: | ESLG TEQR VVGR AAEV PGPE PGQQ EQLV FGSG DAVE LSCP PPGG GPMG PTVW VKDG TGLV PSER VLVG PQRL QVLN ASHE DSGA YSCR QRLT QRVL CHFS VRVT DAPS SGDD EDGE DEAE DTGV DTGA PYWT RPER MDKK LLAV PAAN TVRF RCPA AGNP TPSI SWLK NGRE FRGE HRIG GIKL RHQQ WSLV MESV VPSD RGNY TCVV ENKF GSIR QTYT LDVL ERSP HRPI LQAG LPAN QTAV LGSD VEFH CKVY SDAQ PHIQ WLKH VEVN GSKV GPDG TPYV TVLK TAGA NTTD KELE VLSL HNVT FEDA GEYT CLAG NSIG FSHH SAWL VVLP AEEE LVEA DEAG SVYA G |
Tested Applications: | WB FC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | FGFR3; ACH; CD333; CEK2; HSFGFR3EX; JTK4; fibroblast growth factor receptor 3 |
Positive Sample: | K-562,293T |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Cytoplasmic vesicle, Endoplasmic reticulum, Secreted, Single-pass type I membrane protein. |
Calculated MW: | 75kDa/85kDa/87kDa/88kDa |
Observed MW: | 100-150kDa |
This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described.
Purification Method: | Affinity purification |
Gene ID: | 2261 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |