FGFR2 Monoclonal Antibody (CAB23298)
- SKU:
- CAB23298
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- FC
Description
Product Name: | FGFR2 Monoclonal Antibody |
SKU: | CAB23298 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 22-377 of human FGFR2 (NP_000132.3). |
Sequence: | RPSF SLVE DTTL EPEE PPTK YQIS QPEV YVAA PGES LEVR CLLK DAAV ISWT KDGV HLGP NNRT VLIG EYLQ IKGA TPRD SGLY ACTA SRTV DSET WYFM VNVT DAIS SGDD EDDT DGAE DFVS ENSN NKRA PYWT NTEK MEKR LHAV PAAN TVKF RCPA GGNP MPTM RWLK NGKE FKQE HRIG GYKV RNQH WSLI MESV VPSD KGNY TCVV ENEY GSIN HTYH LDVV ERSP HRPI LQAG LPAN ASTV VGGD VEFV CKVY SDAQ PHIQ WIKH VEKN GSKY GPDG LPYL KVLK AAGV NTTD KEIE VLYI RNVT FEDA |
Tested Applications: | WB FC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 FC,1:100 - 1:500 |
Synonyms: | BEK; JWS; BBDS; CEK3; CFD1; ECT1; KGFR; TK14; TK25; BFR-1; CD332; K-SAM; FGFR2 |
Positive Sample: | T-47D |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Cytoplasmic vesicle, Golgi apparatus, Secreted. |
Calculated MW: | 92kDa |
Observed MW: | 145kDa |
The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
Purification Method: | Affinity purification |
Gene ID: | 2263 |
Clone Number: | ARC60257 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3. |