The FGFR2 Monoclonal Antibody is a powerful tool for researchers studying FGFR2, a protein that plays a crucial role in cell growth, differentiation, and survival. This antibody, generated in mice, is highly specific to FGFR2 and is validated for use in immunohistochemistry applications.FGFR2 is a receptor tyrosine kinase involved in various biological processes, including development, tissue repair, and angiogenesis. Dysregulation of FGFR2 signaling has been linked to a variety of diseases, making it a promising target for therapeutic intervention. The FGFR2 Monoclonal Antibody allows for the precise detection and visualization of FGFR2 expression in tissue samples, enabling researchers to better understand its role in cancer, developmental disorders, and other pathological conditions.
With its high specificity and sensitivity, the FGFR2 Monoclonal Antibody is an essential tool for investigating the biology of FGFR2 and exploring its potential as a therapeutic target. Researchers in the fields of oncology, developmental biology, and molecular medicine will find this antibody invaluable for their studies.
Product Name:
FGFR2 Monoclonal Antibody
SKU:
CAB23298
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 22-377 of human FGFR2 (NP_000132.3).
The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
Purification Method:
Affinity purification
Gene ID:
2263
Clone Number:
ARC60257
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates, using FGFR2 Rabbit mAb (CAB23298) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 60s.
