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FGFR2 Rabbit Polyclonal Antibody (CAB12436)

SKU:
CAB12436
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Death
  • Cell Death Antibodies 1 Anti-FGFR2 Antibody CAB12436
  • Cell Death Antibodies 1 Anti-FGFR2 Antibody CAB12436
  • Cell Death Antibodies 1 Anti-FGFR2 Antibody CAB12436
  • Cell Death Antibodies 1 Anti-FGFR2 Antibody CAB12436
€139 - €419
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Description

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FGFR2 Rabbit Polyclonal Antibody (CAB12436)

The FGFR2 Polyclonal Antibody (CAB12436) is a valuable tool for researchers studying the Fibroblast Growth Factor Receptor 2 (FGFR2) protein. This antibody, raised in rabbits, is highly specific and reactive with human samples, making it ideal for use in Western blot applications.FGFR2 is a cell surface receptor involved in various cellular processes, including cell growth, differentiation, and survival. Dysregulation of FGFR2 has been implicated in a variety of diseases, including cancer and skeletal disorders.

The FGFR2 Polyclonal Antibody binds specifically to FGFR2, enabling researchers to detect and analyze the protein in a range of cell types.By studying the expression and activity of FGFR2, researchers can gain valuable insights into the role of this protein in disease pathogenesis and potentially identify new therapeutic targets. The FGFR2 Polyclonal Antibody is an essential tool for advancing our understanding of FGFR2 biology and developing targeted therapies for FGFR2-related diseases.

Product Name:FGFR2 Rabbit Polyclonal Antibody
SKU:CAB12436
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 360-462 of human FGFR2 (NP_000132.3).
Sequence:LPAP GREK EITA SPDY LEIA IYCI GVFL IACM VVTV ILCR MKNT TKKP DFSS QPAV HKLT KRIP LRRQ VTVS AESS SSMN SNTP LVRI TTRL SSTA DTPM LAG
Tested Applications:WB IF/ICC ELISA
Recommended Dilution:WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200
Synonyms:BEK; JWS; BBDS; CEK3; CFD1; ECT1; KGFR; TK14; TK25; BFR-1; CD332; K-SAM; FGFR2
Positive Sample:MCF7
Conjugate:Unconjugated
Cellular Localization:Cell membrane, Cytoplasmic vesicle, Golgi apparatus, Secreted, Single-pass type I membrane protein.
Calculated MW:92kDa
Observed MW:145kDa

The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene.

Purification Method:Affinity purification
Gene ID:2263
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Product ImageWestern blot analysis of extracts of MCF7 cells, using FGFR2 antibody (CAB12436) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.

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