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FGFR1OP2 Antibody (PACO16343)

SKU:
PACO16343
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
  • FGFR1OP2 Antibody PACO16343
  • FGFR1OP2 Antibody PACO16343
€339

Description

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FGFR1OP2 Antibody (PACO16343)

The FGFR1OP2 Polyclonal Antibody (PAC016343) is a powerful tool for researchers studying FGFR1OP2, a protein known to interact with fibroblast growth factor receptors (FGFRs) and play a role in various cellular processes. This polyclonal antibody, raised in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding to the FGFR1OP2 protein, this antibody allows for accurate detection and analysis in a wide range of cell types, making it ideal for investigations in cell biology and cancer research.

FGFR1OP2's interaction with FGFRs suggests its potential involvement in key signaling pathways critical for cell growth, differentiation, and survival. Researchers studying cancer, developmental disorders, and other diseases linked to aberrant FGFR signaling pathways will find this antibody invaluable for dissecting the role of FGFR1OP2 in these contexts. A deeper understanding of FGFR1OP2 function could lead to the development of targeted therapies aimed at manipulating FGFR signaling for therapeutic benefit.

Antibody Name:FGFR1OP2 Antibody (PACO16343)
Antibody SKU:PACO16343
Size:50ul
Host Species:Rabbit
Tested Applications:ELISA, IHC
Recommended Dilutions:ELISA:1:2000-1:5000, IHC:1:50-1:200
Species Reactivity:Human, Mouse, Rat
Immunogen:Fusion protein of human FGFR1OP2
Form:Liquid
Storage Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:Antigen affinity purification
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageThe image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using PACO16343(FGFR1OP2 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200).
Product ImageThe image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO16343(FGFR1OP2 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200).
Background:acid, c and basic fibroblast growth factors (FGFs) are members of a family of multifunctional polypeptide growth factors that stimulate proliferation of cells of mesenchymal, epithelial and neuroectodermal origin. Like other growth factors, FGFs act by binding and activating specific cell surface receptors which include the Flg receptor (FGFR-1) and the Bek receptor (FGFR-2), as well as FGFR-3, FGFR-4, FGFR-5 and FGFR-6. FGFR1OP2 (FGFR1 oncogene partner 2), also known as HSPC123, is a 253 amino acid, cytoplasmic protein that is expressed in spleen, thymus and bone marrow and is involved in wound healing under normal cellular conditions. Additionally, FGFR1OP2 may also exist as an aberrant fusion protein with Flg and it is thought that the FGFR1OP2-Flg mutant may play a role in the pathogenesis of stem cell myeloproliferative disorder (MPD). Multiple isoforms of FGFR1OP2 exist due to alternative splicing events.
Synonyms:FGFR1 oncogene partner 2
UniProt Protein Function:FGFR1OP2: May be involved in wound healing pathway. A chromosomal aberration involving FGFR1OP2 may be a cause of stem cell myeloproliferative disorder (MPD). Insertion ins(12;8)(p11;p11p22) with FGFR1. MPD is characterized by myeloid hyperplasia, eosinophilia and T-cell or B-cell lymphoblastic lymphoma. In general it progresses to acute myeloid leukemia. The fusion protein FGFR1OP2-FGFR1 may exhibit constitutive kinase activity and be responsible for the transforming activity. Belongs to the SIKE family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Unknown functionChromosomal Location of Human Ortholog: 12p11.23Cellular Component: cytosolMolecular Function: protein binding; protein-tyrosine kinase activity
UniProt Protein Details:
NCBI Summary:
UniProt Code:Q9NVK5
NCBI GenInfo Identifier:74734519
NCBI Gene ID:26127
NCBI Accession:Q9NVK5.1
UniProt Secondary Accession:Q9NVK5,Q6R955, Q8N5L7, Q9P034, Q9UFK8
UniProt Related Accession:Q9NVK5
Molecular Weight:20,175 Da
NCBI Full Name:FGFR1 oncogene partner 2
NCBI Synonym Full Names:FGFR1 oncogene partner 2
NCBI Official Symbol:FGFR1OP2  
NCBI Official Synonym Symbols:WIT3.0; HSPC123-like  
NCBI Protein Information:FGFR1 oncogene partner 2
UniProt Protein Name:FGFR1 oncogene partner 2
UniProt Synonym Protein Names:
Protein Family:FGFR1 oncogene partner
UniProt Gene Name:FGFR1OP2  
UniProt Entry Name:FGOP2_HUMAN
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FGFR1OP2 Antibody (PACO09288)
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