The FGFR1OP2 Polyclonal Antibody (PAC016342) is a valuable tool for researchers studying FGFR1OP2, a protein that plays a role in various biological processes, including cell growth and differentiation. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the FGFR1OP2 protein, this antibody enables researchers to detect and analyze the protein in different cell types, making it a versatile tool for studies in cell biology and cancer research.FGFR1OP2, also known as fibroblast growth factor receptor 1 oncogene partner 2, is involved in the regulation of FGFR signaling pathways, which are essential for cell proliferation and survival.
Dysregulation of FGFR1OP2 has been implicated in various diseases, including cancer, making it a promising target for therapeutic interventions. Understanding the function and regulation of FGFR1OP2 is crucial for developing targeted therapies that can effectively modulate cell growth and survival pathways in disease contexts.Overall, the FGFR1OP2 Polyclonal Antibody is a reliable reagent for researchers studying FGFR1OP2 and its role in cell biology and cancer. Its high reactivity and specificity make it a valuable tool for investigating the function of FGFR1OP2 in different biological processes and disease states.
Antibody Name:
FGFR1OP2 Antibody (PACO16342)
Antibody SKU:
PACO16342
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:50-1:200
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Fusion protein of human FGFR1OP2
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO16342(FGFR1OP2 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200).
Background:
acid, c and basic fibroblast growth factors (FGFs) are members of a family of multifunctional polypeptide growth factors that stimulate proliferation of cells of mesenchymal, epithelial and neuroectodermal origin. Like other growth factors, FGFs act by binding and activating specific cell surface receptors which include the Flg receptor (FGFR-1) and the Bek receptor (FGFR-2), as well as FGFR-3, FGFR-4, FGFR-5 and FGFR-6. FGFR1OP2 (FGFR1 oncogene partner 2), also known as HSPC123, is a 253 amino acid, cytoplasmic protein that is expressed in spleen, thymus and bone marrow and is involved in wound healing under normal cellular conditions. Additionally, FGFR1OP2 may also exist as an aberrant fusion protein with Flg and it is thought that the FGFR1OP2-Flg mutant may play a role in the pathogenesis of stem cell myeloproliferative disorder (MPD). Multiple isoforms of FGFR1OP2 exist due to alternative splicing events.
Synonyms:
FGFR1 oncogene partner 2
UniProt Protein Function:
FGFR1OP2: May be involved in wound healing pathway. A chromosomal aberration involving FGFR1OP2 may be a cause of stem cell myeloproliferative disorder (MPD). Insertion ins(12;8)(p11;p11p22) with FGFR1. MPD is characterized by myeloid hyperplasia, eosinophilia and T-cell or B-cell lymphoblastic lymphoma. In general it progresses to acute myeloid leukemia. The fusion protein FGFR1OP2-FGFR1 may exhibit constitutive kinase activity and be responsible for the transforming activity. Belongs to the SIKE family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Unknown functionChromosomal Location of Human Ortholog: 12p11.23Cellular Component: cytosolMolecular Function: protein binding; protein-tyrosine kinase activity
