The FGFR1OP2 Polyclonal Antibody (PACO09288) is a valuable tool for researchers studying FGFR1OP2, a protein involved in cell signaling and regulation. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the FGFR1OP2 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it ideal for research in fields such as cell biology and cancer biology.FGFR1OP2, also known as FGFR1 Oncogene Partner 2, is a key player in the FGFR signaling pathway, which is crucial for cell growth, differentiation, and survival.
Dysregulation of this pathway has been implicated in various diseases, including cancer and developmental disorders. The FGFR1OP2 antibody allows researchers to investigate the role of this protein in disease development and progression, providing valuable insights for the development of potential therapeutic strategies targeting the FGFR1OP2 signaling pathway.
FGFR1OP2: May be involved in wound healing pathway. A chromosomal aberration involving FGFR1OP2 may be a cause of stem cell myeloproliferative disorder (MPD). Insertion ins(12;8)(p11;p11p22) with FGFR1. MPD is characterized by myeloid hyperplasia, eosinophilia and T-cell or B-cell lymphoblastic lymphoma. In general it progresses to acute myeloid leukemia. The fusion protein FGFR1OP2-FGFR1 may exhibit constitutive kinase activity and be responsible for the transforming activity. Belongs to the SIKE family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Unknown functionChromosomal Location of Human Ortholog: 12p11.23Cellular Component: cytosolMolecular Function: protein binding; protein-tyrosine kinase activity
