The FGFR1 Polyclonal Antibody is a valuable tool for researchers studying the Fibroblast Growth Factor Receptor 1 (FGFR1) protein. FGFR1 is a cell surface receptor involved in cell growth, differentiation, and angiogenesis, making it a critical target for cancer and developmental biology research. This antibody, produced in rabbits, is highly specific and reactive with human samples, providing reliable results in Western blot applications. By binding to the FGFR1 protein, researchers can accurately detect and analyze FGFR1 expression in various cell types, aiding in the study of signaling pathways and potential therapeutic targets.
The importance of FGFR1 in cancer progression and development makes this antibody an essential component in studying tumor growth and metastasis. By understanding the role of FGFR1 in promoting cell proliferation and survival, researchers can potentially develop novel strategies for cancer treatment. Overall, the FGFR1 Polyclonal Antibody is a valuable tool for researchers interested in investigating the role of FGFR1 in cancer biology and other cellular processes, offering insights that may lead to new therapeutic interventions.
Product Name:
FGFR1 Polyclonal Antibody
SKU:
CAB22005
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 700-822 of human FGFR1 (NP_075598.2).
The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.
Purification Method:
Affinity purification
Gene ID:
2260
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates, using FGFR1 Rabbit pAb (CAB22005) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Negative control (NC): HT-29Exposure time: 60s.
