The FGFR1 Polyclonal Antibody (CAB0082) is a valuable tool for researchers studying fibroblast growth factor receptor 1 (FGFR1), a critical player in cell growth, development, and differentiation. This antibody, generated in rabbits, is highly specific to FGFR1 in human samples and has been validated for use in Western blot applications.FGFR1 is a key receptor for FGF ligands and is involved in a variety of cellular processes, including angiogenesis, wound healing, and tissue regeneration. Dysregulation of FGFR1 signaling has been implicated in a range of diseases, including cancer, skeletal disorders, and developmental abnormalities.
By specifically targeting FGFR1, this antibody allows for the detection and analysis of FGFR1 expression in various cell types, making it an essential tool for research in oncology, developmental biology, and regenerative medicine.The FGFR1 Polyclonal Antibody is a reliable resource for scientists seeking to explore the mechanisms underlying FGFR1 signaling and its potential as a therapeutic target in disease settings. Its high sensitivity and specificity make it an indispensable tool for investigating the role of FGFR1 in normal physiological processes and pathological conditions.
Product Name:
FGFR1 Rabbit Polyclonal Antibody
SKU:
CAB0082
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 300-400 of human FGFR1 (NP_075598.2).
Cell membrane, Cytoplasm, Cytoplasmic vesicle, Nucleus, Single-pass type I membrane protein, cytosol.
Calculated MW:
92kDa
Observed MW:
100-120kDa
The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.
Purification Method:
Affinity purification
Gene ID:
2260
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using FGFR1 Rabbit pAb (CAB0082) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
