FGFR1 Monoclonal Antibody (CAB23390)
- SKU:
- CAB23390
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
Product Name: | FGFR1 Monoclonal Antibody |
SKU: | CAB23390 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 38-123 of human FGFR1 (NP_075598.2). |
Sequence: | GTGG AAGT GGAG TCCT TCCT GGTC CACC CCGG TGAC CTGC TGCA GCTT CGCT GTCG GCTG CGGG ACGA TGTG CAGA GCAT CAAC TGGC TGCG GGAC GGGG TGCA GCTG GCGG AAAG CAAC CGCA CCCG CATC ACAG GGGA GGAG GTGG AGGT GCAG GACT CCGT GCCC GCAG ACTC CGGC CTCT ATGC TTGC GTAA CCAG CAGC CCCT CGGG CAGT GACA CCAC CTAC TTCT CCGT CAAT GTTT CAGA TGCT CTCC CC |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:2000 - 1:4000 |
Synonyms: | CEK; FLG; HH2; OGD; ECCL; FLT2; KAL2; BFGFR; CD331; FGFBR; FLT-2; HBGFR; N-SAM; FGFR-1; HRTFDS; bFGF-R-1; FGFR1 |
Positive Sample: | U-251MG,Mouse brain,Rat brain |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Cytoplasm, Cytoplasmic vesicle, Nucleus, Single-pass type I membrane protein, cytosol. |
Calculated MW: | 92kDa |
Observed MW: | 122kDa |
The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.
Purification Method: | Affinity purification |
Gene ID: | 2260 |
Clone Number: | ARC53422 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3. |