The FGFR1 Monoclonal Antibody (CAB23390) is a key tool for research involving Fibroblast Growth Factor Receptor 1 (FGFR1), a cell surface receptor involved in various cellular processes, including cell growth and differentiation. This antibody, derived from mouse monoclonal cells, exhibits high specificity and sensitivity for human samples, making it ideal for experiments such as Western blotting and immunohistochemistry.FGFR1 is a crucial player in signaling pathways that regulate cell proliferation, angiogenesis, and tissue development, making it a target of interest in cancer research and other disease studies.
Understanding the expression and activation of FGFR1 can provide valuable insights into the mechanisms underlying tumorigenesis and potential therapeutic interventions. The FGFR1 Monoclonal Antibody (CAB23390) offers researchers a reliable tool for detecting and studying FGFR1 protein expression in various cell types and tissues, furthering our understanding of its role in health and disease.
Product Name:
FGFR1 Monoclonal Antibody
SKU:
CAB23390
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 38-123 of human FGFR1 (NP_075598.2).
Cell membrane, Cytoplasm, Cytoplasmic vesicle, Nucleus, Single-pass type I membrane protein, cytosol.
Calculated MW:
92kDa
Observed MW:
122kDa
The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.
Purification Method:
Affinity purification
Gene ID:
2260
Clone Number:
ARC53422
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates, using FGFR1 Rabbit mAb (CAB23390) at 1:3600 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
