The FGFBP3 Polyclonal Antibody (PAC062531) is a valuable tool for research involving FGFBP3, a protein that plays a crucial role in regulating the function of fibroblast growth factors (FGFs). This antibody, raised in rabbits, is highly specific and reactive to human samples, making it ideal for use in various research applications, including Western blotting.FGFBP3 is known to interact with FGFs, modulating their activity and stability, thus influencing processes such as cell growth, differentiation, and angiogenesis. By targeting FGFBP3 with this antibody, researchers can gain insights into the mechanisms underlying these vital biological functions.
Additionally, studying FGFBP3 may provide valuable information for developing new therapeutic strategies targeting FGF signaling pathways in diseases such as cancer and cardiovascular disorders.Overall, the FGFBP3 Polyclonal Antibody is a reliable tool for investigating the role of FGFBP3 in cellular processes and disease pathways, offering researchers the opportunity to expand their understanding of FGF signaling and its implications in various physiological and pathological contexts.
Antibody Name:
FGFBP3 Antibody (PACO62531)
Antibody SKU:
PACO62531
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Peptide sequence from Human Fibroblast growth factor-binding protein 3 protein (192-209AA)
IHC image of PACO62531 diluted at 1:100 and staining in paraffin-embedded human ovarian cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Background:
Heparin-binding protein which binds to FGF2, prevents binding of FGF2 to heparin and probably inhibits immobilization of FGF2 on extracellular matrix glycosaminoglycans, allowing its release and subsequent activation of FGFR signaling which leads to increased vascular permeability.
Synonyms:
Fibroblast growth factor-binding protein 3 (FGF-BP3) (FGF-binding protein 3) (FGFBP-3), FGFBP3, C10orf13
