null

FGF5 Antibody (PACO01903)

SKU:
PACO01903
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€269
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS

FGF5 Antibody (PACO01903)

The FGF5 Polyclonal Antibody (PACO01903) is an essential tool for research involving FGF5, a member of the fibroblast growth factor (FGF) family that plays a key role in cell proliferation and differentiation. This antibody, produced in rabbits, exhibits strong reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the FGF5 protein, this antibody facilitates the detection and analysis of FGF5 in various cell types, making it well-suited for investigations in cell biology and developmental biology.

FGF5 is known to be involved in hair growth regulation and stem cell maintenance, making it a target of interest in studies related to hair disorders and regenerative medicine. Its role in cell signaling pathways and tissue development also positions it as a potential therapeutic target for conditions like cancer and wound healing. The FGF5 Polyclonal Antibody is a valuable resource for researchers seeking to elucidate the functions and mechanisms of FGF5 in health and disease.

Antibody Name:FGF5 Antibody
Antibody SKU:PACO01903
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB
Recommended Dilutions:WB:1:500-1:2000
Species Reactivity:Human
Immunogen:synthesized peptide derived from the C-terminal region of human FGF-5.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:FGF5; Fibroblast growth factor 5; FGF-5; Heparin-binding growth factor 5; HBGF-5; Smag-82
UniProt Protein Function:FGF5: Plays an important role in the regulation of cell proliferation and cell differentiation. Required for normal regulation of the hair growth cycle. Functions as an inhibitor of hair elongation by promoting progression from anagen, the growth phase of the hair follicle, into catagen the apoptosis-induced regression phase. Belongs to the heparin-binding growth factors family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Secreted, signal peptide; Cytokine; Oncoprotein; Secreted

Chromosomal Location of Human Ortholog: 4q21

Cellular Component: extracellular region; extracellular space

Molecular Function:1-phosphatidylinositol-3-kinase activity; fibroblast growth factor receptor binding; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; protein-tyrosine kinase activity; Ras guanyl-nucleotide exchange factor activity

Biological Process: cell proliferation; cell-cell signaling; fibroblast growth factor receptor signaling pathway; MAPKKK cascade; nervous system development; phosphoinositide-mediated signaling; positive regulation of cell proliferation; regulation of phosphoinositide 3-kinase cascade

Disease: Trichomegaly

NCBI Summary:The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified as an oncogene, which confers transforming potential when transfected into mammalian cells. Targeted disruption of the homolog of this gene in mouse resulted in the phenotype of abnormally long hair, which suggested a function as an inhibitor of hair elongation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
UniProt Code:P12034
NCBI GenInfo Identifier:85700417
NCBI Gene ID:2250
NCBI Accession:P12034.4
UniProt Secondary Accession:P12034,O75846, Q3Y8M3, Q8NF90, B2R554,
UniProt Related Accession:P12034
Molecular Weight:13,006 Da
NCBI Full Name:Fibroblast growth factor 5
NCBI Synonym Full Names:fibroblast growth factor 5
NCBI Official Symbol:FGF5  
NCBI Official Synonym Symbols:HBGF-5; TCMGLY; Smag-82  
NCBI Protein Information:fibroblast growth factor 5
UniProt Protein Name:Fibroblast growth factor 5
UniProt Synonym Protein Names:Heparin-binding growth factor 5; HBGF-5; Smag-82
Protein Family:Fibroblast growth factor
UniProt Gene Name:FGF5  
UniProt Entry Name:FGF5_HUMAN

Related Products