The FGF23 Polyclonal Antibody (CAB6124) is a valuable tool for researchers studying Fibroblast Growth Factor 23 (FGF23), a protein known for its role in phosphate homeostasis and regulating vitamin D metabolism. This antibody, produced in rabbits, exhibits high reactivity specifically with human samples and has been validated for use in Western blot applications.FGF23 is a critical factor in the regulation of phosphate levels in the body, working to maintain systemic mineral balance through its interactions with various target tissues. Dysregulation of FGF23 signaling has been linked to disorders such as hypophosphatemic rickets and tumoral calcinosis, making it a target of interest in both clinical and basic research settings.
With its ability to specifically detect and bind to FGF23, the CAB6124 antibody enables researchers to analyze the expression and function of this important protein in a variety of cell types and tissues. This antibody is an essential tool for investigations into the mechanisms underlying FGF23-related diseases and the development of targeted therapies for these conditions.
Product Name:
FGF23 Rabbit Polyclonal Antibody
SKU:
CAB6124
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 25-251 of human FGF23 (NP_065689.1).
This gene encodes a member of the fibroblast growth factor family of proteins, which possess broad mitogenic and cell survival activities and are involved in a variety of biological processes. The product of this gene regulates phosphate homeostasis and transport in the kidney. The full-length, functional protein may be deactivated via cleavage into N-terminal and C-terminal chains. Mutation of this cleavage site causes autosomal dominant hypophosphatemic rickets (ADHR). Mutations in this gene are also associated with hyperphosphatemic familial tumoral calcinosis (HFTC).
Purification Method:
Affinity purification
Gene ID:
8074
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using FGF23 antibody (CAB6124) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
