The FGF23 Polyclonal Antibody (CAB14073) is a valuable tool for researchers studying FGF23, a key protein involved in phosphate and vitamin D metabolism. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. It specifically targets the FGF23 protein, allowing for precise detection and analysis in various cell types, making it well-suited for investigations in the fields of endocrinology and bone metabolism.
FGF23 is a crucial hormone in the regulation of phosphate levels in the body, particularly in the kidneys and bones. Dysregulation of FGF23 has been implicated in various disorders, including chronic kidney disease and hypophosphatemic rickets. By studying the function and expression of FGF23 using this antibody, researchers can gain insights into the pathophysiology of these conditions and potentially identify new therapeutic targets for intervention.
Product Name:
FGF23 Rabbit Polyclonal Antibody
SKU:
CAB14073
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 91-190 of human FGF23 (NP_065689.1).
This gene encodes a member of the fibroblast growth factor family of proteins, which possess broad mitogenic and cell survival activities and are involved in a variety of biological processes. The product of this gene regulates phosphate homeostasis and transport in the kidney. The full-length, functional protein may be deactivated via cleavage into N-terminal and C-terminal chains. Mutation of this cleavage site causes autosomal dominant hypophosphatemic rickets (ADHR). Mutations in this gene are also associated with hyperphosphatemic familial tumoral calcinosis (HFTC).
Purification Method:
Affinity purification
Gene ID:
8074
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from wild type (WT) and 293T cells transfected with FGF23 using FGF23 Rabbit pAb(CAB14073) at 1:600 dilution.Secondary antibody:HRP Goat Anti-Rabbit IgG (H+L)(CABS014) at 1:10000 dilution.Lysates/proteins: 20 μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection:ECL Basic Kit (AbGn00020).Exposuretime: 1s.
