The FGF16 Polyclonal Antibody (PAC06303) is a valuable tool for researchers studying fibroblast growth factor 16 (FGF16), a member of the FGF family known for its role in various cellular processes, including cell growth, differentiation, and angiogenesis. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.FGF16 is a key regulator of cell proliferation and survival, making it a focus of research in developmental biology, cancer, and tissue regeneration. By specifically binding to the FGF16 protein, this antibody enables precise detection and analysis in a variety of cell types, making it ideal for investigations in molecular biology and biomedicine.
Understanding the functions and mechanisms of action of FGF16 is essential for elucidating its potential therapeutic applications in diseases such as cancer, cardiovascular disorders, and neurodegenerative conditions. The FGF16 Polyclonal Antibody provides researchers with a reliable tool to explore the role of FGF16 in health and disease, paving the way for innovative treatments and interventions targeting this important signaling molecule.
Antibody Name:
FGF16 Antibody (PACO63303)
Antibody SKU:
PACO63303
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Fibroblast growth factor 16 protein (1-207AA)
IHC image of PACO63303 diluted at 1:100 and staining in paraffin-embedded human placenta tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Background:
Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation, and is required for normal cardiomyocyte proliferation and heart development.
Synonyms:
Fibroblast growth factor 16 (FGF-16), FGF16
UniProt Protein Function:
FGF16: Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation, and is required for normal cardiomyocyte proliferation and heart development. Belongs to the heparin-binding growth factors family.Protein type: CytokineChromosomal Location of Human Ortholog: Xq13Cellular Component: extracellular region; extracellular spaceMolecular Function: 1-phosphatidylinositol-3-kinase activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; protein-tyrosine kinase activity; Ras guanyl-nucleotide exchange factor activityBiological Process: cell-cell signaling; fibroblast growth factor receptor signaling pathway; MAPKKK cascade; metabolic process; organ morphogenesis; phosphoinositide-mediated signaling; regulation of endothelial cell proliferation; regulation of MAP kinase activity; regulation of phosphoinositide 3-kinase cascade; response to temperature stimulus; signal transductionDisease: Metacarpal 4-5 Fusion
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of a family of proteins that are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene is expressed in cardiac cells and is required for proper heart development. Mutation in this gene was also observed in individuals with metacarpal 4-5 fusion. [provided by RefSeq, Mar 2014]
