The FGF16 Polyclonal Antibody (Paco19657) is a valuable tool for researchers studying fibroblast growth factor 16 (FGF16), a member of the FGF family known for its role in cell growth and differentiation. This antibody, produced in rabbits, is highly specific to FGF16 and has been validated for use in various research applications, including Western blot and immunohistochemistry.FGF16 is a key player in various biological processes, including embryonic development, angiogenesis, and tissue repair. Dysregulation of FGF16 has been linked to several diseases, such as cancer and cardiovascular disorders, making it a promising target for therapeutic interventions.
By using the FGF16 Polyclonal Antibody, researchers can accurately detect and analyze FGF16 levels in different cell types and tissues, shedding light on its function and potential implications in disease pathology.With its high specificity and reliability, the FGF16 Polyclonal Antibody is a valuable tool for investigating the mechanisms of FGF16 signaling and its role in normal physiology and disease progression. Researchers in the fields of developmental biology, cancer research, and regenerative medicine can benefit from the use of this antibody to advance their understanding of FGF16 biology and explore its therapeutic potential.
Antibody Name:
FGF16 Antibody (PACO19657)
Antibody SKU:
PACO19657
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:2000, IHC:1:25-1:100
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Synthetic peptide of human FGF16
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO19657(FGF16 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using PACO19657(FGF16 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The rat homolog is predominantly expressed in embryonic brown adipose tissue and has significant mitogenic activity, which suggests a role in proliferation of embryonic brown adipose tissue.
Synonyms:
fibroblast growth factor 16
UniProt Protein Function:
FGF16: Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation, and is required for normal cardiomyocyte proliferation and heart development. Belongs to the heparin-binding growth factors family.Protein type: CytokineChromosomal Location of Human Ortholog: Xq13Cellular Component: extracellular region; extracellular spaceMolecular Function: 1-phosphatidylinositol-3-kinase activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; protein-tyrosine kinase activity; Ras guanyl-nucleotide exchange factor activityBiological Process: cell-cell signaling; fibroblast growth factor receptor signaling pathway; MAPKKK cascade; metabolic process; organ morphogenesis; phosphoinositide-mediated signaling; regulation of endothelial cell proliferation; regulation of MAP kinase activity; regulation of phosphoinositide 3-kinase cascade; response to temperature stimulus; signal transductionDisease: Metacarpal 4-5 Fusion
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of a family of proteins that are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene is expressed in cardiac cells and is required for proper heart development. Mutation in this gene was also observed in individuals with metacarpal 4-5 fusion. [provided by RefSeq, Mar 2014]
