The FGD6 Polyclonal Antibody (PAC037114) is a vital tool for researchers studying FGD6, a gene involved in cell signaling pathways and actin cytoskeleton regulation. This antibody, produced in rabbits, exhibits high specificity and reactivity towards human FGD6 protein, making it ideal for Western blot applications. By binding to FGD6, this antibody facilitates the detection and analysis of FGD6 expression in various cell types, offering valuable insights into signaling mechanisms and potential therapeutic targets.FGD6 is a key player in cellular processes such as cell migration, adhesion, and proliferation, making it a target of interest in cancer and developmental biology research.
Its role in regulating actin dynamics and signaling cascades underscores its importance in cell function and disease progression. Researchers exploring FGD6 function aim to unravel its contribution to disease states like cancer, neurological disorders, and cardiovascular conditions, paving the way for novel therapeutic interventions.Overall, the FGD6 Polyclonal Antibody (PAC037114) provides researchers with a reliable tool for investigating the role of FGD6 in physiological and pathological conditions, offering new perspectives on cellular signaling and potential treatment strategies.
Western Blot. Positive WB detected in: K562 whole cell lysate. All lanes: FGD6 antibody at 2.8µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 161, 155 kDa. Observed band size: 161 kDa.
Immunocytochemistry analysis of human adrenal gland tissue using PACO37114 at dilution of 1:100.
Immunocytochemistry analysis of human brain tissue using PACO37114 at dilution of 1:100.
Background:
May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. May play a role in regulating the actin cytoskeleton and cell shape.
Synonyms:
FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24), FGD6, KIAA1362 ZFYVE24
UniProt Protein Function:
FGD6: May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. May play a role in regulating the actin cytoskeleton and cell shape. 2 isoforms of the human protein are produced by alternative splicing.Protein type: GEFs; GEFs, Rac/RhoChromosomal Location of Human Ortholog: 12q22Cellular Component: cytoplasm; Golgi apparatus; lamellipodium; ruffleMolecular Function: guanyl-nucleotide exchange factor activity; small GTPase bindingBiological Process: actin cytoskeleton organization and biogenesis; cytoskeleton organization and biogenesis; filopodium formation; regulation of cell shape; regulation of GTPase activity
