UniProt Protein Function: | FGD3: Promotes the formation of filopodia. May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape. 2 isoforms of the human protein are produced by alternative splicing.Protein type: GEFs; GEFs, Rac/RhoChromosomal Location of Human Ortholog: -Cellular Component: cytoplasm; cytosol; Golgi apparatus; lamellipodium; ruffleMolecular Function: guanyl-nucleotide exchange factor activity; Rho guanyl-nucleotide exchange factor activity; small GTPase bindingBiological Process: actin cytoskeleton organization and biogenesis; cytoskeleton organization and biogenesis; filopodium formation; positive regulation of apoptosis; regulation of cell shape; regulation of GTPase activity; regulation of small GTPase mediated signal transduction |
UniProt Protein Details: | |
NCBI Summary: | |
UniProt Code: | Q5JSP0 |
NCBI GenInfo Identifier: | 61213216 |
NCBI Gene ID: | 89846 |
NCBI Accession: | Q5JSP0.1 |
UniProt Secondary Accession: | Q5JSP0,Q4VX84, Q7Z7D9, Q8N5G1, F8W7P2 |
UniProt Related Accession: | Q5JSP0 |
Molecular Weight: | 79,273 Da |
NCBI Full Name: | FYVE, RhoGEF and PH domain-containing protein 3 |
NCBI Synonym Full Names: | FYVE, RhoGEF and PH domain containing 3 |
NCBI Official Symbol: | FGD3Â Â |
NCBI Official Synonym Symbols: | ZFYVE5Â Â |
NCBI Protein Information: | FYVE, RhoGEF and PH domain-containing protein 3 |
UniProt Protein Name: | FYVE, RhoGEF and PH domain-containing protein 3 |
UniProt Synonym Protein Names: | Zinc finger FYVE domain-containing protein 5 |
Protein Family: | FYVE, RhoGEF and PH domain-containing protein |
UniProt Gene Name: | FGD3Â Â |
UniProt Entry Name: | FGD3_HUMAN |