The FGD3 Polyclonal Antibody (PACO09281) is a valuable tool for researchers studying FGD3, a gene that plays a crucial role in cell signaling and cytoskeletal organization. This antibody, raised in rabbits, has been validated for use in various applications, including Western blotting and immunofluorescence, and shows high reactivity with human samples.FGD3 is a guanine nucleotide exchange factor involved in the activation of small GTPases, key regulators of cell migration, adhesion, and proliferation. Dysregulation of FGD3 has been implicated in various diseases, including cancer and neurological disorders, making it an important target for further investigation.
By detecting and analyzing FGD3 protein expression in different cell types, this antibody can provide valuable insights into the molecular mechanisms underlying these diseases.Overall, the FGD3 Polyclonal Antibody (PACO09281) is an essential tool for researchers interested in unraveling the functions of FGD3 and its potential implications in disease pathogenesis. With its high specificity and sensitivity, this antibody is sure to enhance research efforts in cell biology, cancer research, and beyond.
FYVE, RhoGEF and PH domain containing 3;FGD3;FLJ00004;MGC117260;ZFYVE5 ;
UniProt Protein Function:
FGD3: Promotes the formation of filopodia. May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape. 2 isoforms of the human protein are produced by alternative splicing.Protein type: GEFs; GEFs, Rac/RhoChromosomal Location of Human Ortholog: -Cellular Component: cytoplasm; cytosol; Golgi apparatus; lamellipodium; ruffleMolecular Function: guanyl-nucleotide exchange factor activity; Rho guanyl-nucleotide exchange factor activity; small GTPase bindingBiological Process: actin cytoskeleton organization and biogenesis; cytoskeleton organization and biogenesis; filopodium formation; positive regulation of apoptosis; regulation of cell shape; regulation of GTPase activity; regulation of small GTPase mediated signal transduction
