The FGD1 Polyclonal Antibody (CAB16709) is a valuable tool for researchers studying the FGD1 protein, a key regulator of cell signaling pathways. This antibody, produced in rabbits, exhibits high reactivity towards human samples and is validated for use in Western blot applications. By specifically binding to FGD1, this antibody enables accurate detection and analysis of the protein in a variety of cell types, making it an essential component of studies in cell biology and signal transduction pathways.FGD1 is involved in the regulation of cell migration, adhesion, and cytoskeletal organization, making it important in processes such as embryonic development and tissue repair.
Dysregulation of FGD1 has been implicated in diseases such as cancer, cardiovascular disorders, and neurological conditions. Therefore, investigating the functions of FGD1 using this antibody may provide insights into potential therapeutic targets for these diseases.Overall, the FGD1 Polyclonal Antibody (CAB16709) is a powerful tool for researchers seeking to understand the role of FGD1 in cellular processes and disease pathogenesis. Its specificity and reliability make it an essential reagent for studies in cell biology, biochemistry, and medicine.
Product Name:
FGD1 Rabbit Polyclonal Antibody
SKU:
CAB16709
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 700-800 of human FGD1 (NP_004454.2).
This gene encodes a protein that contains Dbl (DH) and pleckstrin (PH) homology domains and is similar to the Rho family of small GTP-binding proteins. The encoded protein specifically binds to the Rho family GTPase Cdc42Hs and can stimulate the GDP-GTP exchange of the isoprenylated form of Cdc42Hs. It also stimulates the mitogen activated protein kinase cascade leading to c-Jun kinase SAPK/JNK1 activation. Defects in this gene are the cause of the faciogenital dysplasia in Aarskog-Scott syndrome and a syndromatic form of X-linked cognitive disability.
Purification Method:
Affinity purification
Gene ID:
2245
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using FGD1 Rabbit pAb (CAB16709) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
