FGD1 Rabbit Polyclonal Antibody (CAB16709)
- SKU:
- CAB16709
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | FGD1 Rabbit Polyclonal Antibody |
SKU: | CAB16709 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 700-800 of human FGD1 (NP_004454.2). |
Sequence: | LLNS TNRE DEDT PPNS PNVD LGKR APTP IREK EVTM CMRC QEPF NSIT KRRH HCKA CGHV VCGK CSEF RARL VYDN NRSN RVCT DCYV ALHG VPGS SPAC S |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | AAS; FGDY; MRXS16; ZFYVE3; FGD1 |
Positive Sample: | mouse brain,mouse heart,rat brain |
Conjugate: | Unconjugated |
Cellular Localization: | Cell projection, Cytoplasm, cytoskeleton, lamellipodium, ruffle. |
Calculated MW: | 107kDa |
Observed MW: | 110kDa |
This gene encodes a protein that contains Dbl (DH) and pleckstrin (PH) homology domains and is similar to the Rho family of small GTP-binding proteins. The encoded protein specifically binds to the Rho family GTPase Cdc42Hs and can stimulate the GDP-GTP exchange of the isoprenylated form of Cdc42Hs. It also stimulates the mitogen activated protein kinase cascade leading to c-Jun kinase SAPK/JNK1 activation. Defects in this gene are the cause of the faciogenital dysplasia in Aarskog-Scott syndrome and a syndromatic form of X-linked cognitive disability.
Purification Method: | Affinity purification |
Gene ID: | 2245 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |