The FGD1 Polyclonal Antibody (CAB16374) is a valuable tool for researchers studying FGD1, a protein involved in cell signaling pathways. This antibody, produced in rabbits, demonstrates high reactivity with human samples and has been validated for use in Western blot applications. By binding to the FGD1 protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it suitable for investigations in cell biology and cancer research.
FGD1 plays a crucial role in cellular processes such as cell migration and adhesion, making it a key target for studies on developmental biology and cancer metastasis. Understanding the function of FGD1 can provide insights into disease mechanisms and potential therapeutic strategies. This antibody serves as a valuable tool for researchers looking to unravel the complexities of FGD1-mediated signaling pathways and their implications in various biological processes.
Product Name:
FGD1 Rabbit Polyclonal Antibody
SKU:
CAB16374
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 700-800 of human FGD1 (NP_004454.2).
This gene encodes a protein that contains Dbl (DH) and pleckstrin (PH) homology domains and is similar to the Rho family of small GTP-binding proteins. The encoded protein specifically binds to the Rho family GTPase Cdc42Hs and can stimulate the GDP-GTP exchange of the isoprenylated form of Cdc42Hs. It also stimulates the mitogen activated protein kinase cascade leading to c-Jun kinase SAPK/JNK1 activation. Defects in this gene are the cause of the faciogenital dysplasia in Aarskog-Scott syndrome and a syndromatic form of X-linked cognitive disability.
Purification Method:
Affinity purification
Gene ID:
2245
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using FGD1 Rabbit pAb (CAB16374) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
