The FGA Polyclonal Antibody (CAB1453) is a research tool designed for studying Fibrinogen alpha chain (FGA), a key protein involved in blood clotting and wound healing processes. This antibody, developed through immunization of rabbits, exhibits high reactivity with human samples and is specifically validated for use in Western blot applications.The FGA Polyclonal Antibody binds to the FGA protein, allowing for accurate detection and analysis in a variety of cell types. This makes it an ideal tool for researchers studying hemostasis, thrombosis, and related conditions such as cardiovascular diseases and coagulation disorders.
Understanding the function and activity of FGA is essential for developing targeted therapies and interventions to manage clotting diseases and improve patient outcomes. The FGA Polyclonal Antibody offers a reliable and efficient means of exploring the role of FGA in health and disease, opening new avenues for research in the fields of hematology and cardiovascular medicine.
This gene encodes the alpha subunit of the coagulation factor fibrinogen, which is a component of the blood clot. Following vascular injury, the encoded preproprotein is proteolytically processed by thrombin during the conversion of fibrinogen to fibrin. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia, afibrinogenemia and renal amyloidosis. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that undergoes proteolytic processing.
Purification Method:
Affinity purification
Gene ID:
2243
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using Fibrinogen alpha chain (FGA) Rabbit pAb (CAB1453) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
