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FEZF1 Antibody (PACO60701)

SKU:
PACO60701
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
  • FEZF1 Antibody PACO60701
  • FEZF1 Antibody PACO60701
€359

Description

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FEZF1 Antibody (PACO60701)

The FEZF1 Polyclonal Antibody (PAC060701) is a valuable tool for researchers studying FEZF1, a transcription factor involved in neural development and axon guidance. This antibody is produced in rabbits and has high specificity for FEZF1 in human samples, making it ideal for Western blot applications. By binding to FEZF1, this antibody enables the detection and analysis of this important protein in various cell types, providing valuable insights for studies in neuroscience and developmental biology.FEZF1 is known for its role in directing the formation of neuronal circuits and controlling neural stem cell fate.

Its involvement in neural development makes it a key target for research into neurodevelopmental disorders and neurological diseases. Understanding the function of FEZF1 is essential for unraveling the complexities of brain development and exploring potential therapeutic strategies for related conditions.Overall, the FEZF1 Polyclonal Antibody is a reliable tool for investigating the biological functions of FEZF1 in different cellular contexts, advancing our understanding of neural development and providing potential targets for therapeutic interventions in neurological disorders.

Antibody Name:FEZF1 Antibody (PACO60701)
Antibody SKU:PACO60701
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB, IHC
Recommended Dilutions:ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:200-1:500
Species Reactivity:Human
Immunogen:Recombinant Human Fez family zinc finger protein 1 protein (1-115AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageWestern Blot. Positive WB detected in: U251 whole cell lysate. All lanes: FEZF1 antibody at 6µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 53, 47, 52 kDa. Observed band size: 53 kDa.
Product ImageIHC image of PACO60701 diluted at 1:400 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Background:Transcription repressor. Involved in the axonal projection and proper termination of olfactory sensory neurons (OSN). Plays a role in rostro-caudal patterning of the diencephalon and in prethalamic formation. Expression is required in OSN to cell-autonomously regulate OSN axon projections. Regulates non-cell-autonomously the layer formation of the olfactory bulb development and the interneurons. May be required for correct rostral migration of the interneuron progenitors (By similarity).
Synonyms:Fez family zinc finger protein 1 (Zinc finger protein 312B), FEZF1, FEZ ZNF312B
UniProt Protein Function:FEZF1: Transcription repressor. Involved in the axonal projection and proper termination of olfactory sensory neurons (OSN). Plays a role in rostro-caudal patterning of the diencephalon and in prethalamic formation. Expression is required in OSN to cell-autonomously regulate OSN axon projections. Regulates non-cell-autonomously the layer formation of the olfactory bulb development and the interneurons. May be required for correct rostral migration of the interneuron progenitors. Belongs to the krueppel C2H2-type zinc-finger protein family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: C2H2-type zinc finger protein; Cell development/differentiation; Transcription factor; Motility/polarity/chemotaxisChromosomal Location of Human Ortholog: 7q31.32Biological Process: axon guidance; negative regulation of transcription, DNA-dependentDisease: Hypogonadotropic Hypogonadism 22 With Or Without Anosmia
UniProt Protein Details:
NCBI Summary:This gene encodes a transcriptional repressor that belongs to the zinc finger double domain protein family. The encoded protein is thought to play a role in the embryonic migration of gonadotropin-releasing hormone neurons into the brain. Mutations in this gene are associated with hypogonadotropic hypogonadism-22 with anosmia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
UniProt Code:A0PJY2
NCBI GenInfo Identifier:152032459
NCBI Gene ID:389549
NCBI Accession:A0PJY2.1
UniProt Secondary Accession:A0PJY2,A0PJY3, A4D0W3, B4DUP9, B7ZM98
UniProt Related Accession:A0PJY2
Molecular Weight:51,651 Da
NCBI Full Name:Fez family zinc finger protein 1
NCBI Synonym Full Names:FEZ family zinc finger 1
NCBI Official Symbol:FEZF1  
NCBI Official Synonym Symbols:FEZ; HH22; ZNF312B  
NCBI Protein Information:fez family zinc finger protein 1
UniProt Protein Name:Fez family zinc finger protein 1
UniProt Synonym Protein Names:Zinc finger protein 312B
Protein Family:Fez family zinc finger protein
UniProt Gene Name:FEZF1  
UniProt Entry Name:FEZF1_HUMAN
Secondary Antibody
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)
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