The FEZ1 Polyclonal Antibody (CAB15361) is a valuable tool for researchers studying the FEZ1 protein, a critical regulator of neuronal development and function. This antibody, produced in rabbits, demonstrates high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the FEZ1 protein, researchers can accurately detect and analyze its expression in various cell types, making it ideal for studies in neuroscience and neurodegenerative diseases.FEZ1, also known as fasciculation and elongation protein zeta 1, is essential for axon guidance and neurite outgrowth, making it a key player in neuronal development and connectivity.
Dysregulation of FEZ1 has been linked to conditions such as Alzheimer's disease, Parkinson's disease, and schizophrenia, highlighting its importance in neurological disorders. By uncovering the mechanisms underlying FEZ1's function, researchers can gain insights into potential therapeutic targets for these debilitating conditions.
Product Name:
FEZ1 Rabbit Polyclonal Antibody
SKU:
CAB15361
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human FEZ1 (NP_005094.1).
This gene is an ortholog of the C. elegans unc-76 gene, which is necessary for normal axonal bundling and elongation within axon bundles. Expression of this gene in C. elegans unc-76 mutants can restore to the mutants partial locomotion and axonal fasciculation, suggesting that it also functions in axonal outgrowth. The N-terminal half of the gene product is highly acidic. Alternatively spliced transcript variants encoding different isoforms of this protein have been described.
Purification Method:
Affinity purification
Gene ID:
9638
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from U-251MG cells, using FEZ1 Rabbit pAb (CAB15361) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
