The FES Polyclonal Antibody (CAB2578) is specifically designed for research involving the FES protein, a non-receptor protein tyrosine kinase involved in cell signaling pathways. This antibody, raised in rabbits, is highly reactive with human samples and is validated for use in Western blot and immunohistochemistry applications. By binding to the FES protein, researchers can effectively detect and analyze its expression in various cell types, making it a valuable tool for studies in cancer research and cell signaling.
The FES protein is known for its role in cell proliferation, differentiation, and survival, making it a critical player in oncogenesis and tumor progression. Understanding the function and regulation of FES is essential for developing targeted therapies for cancer and other diseases related to abnormal cell growth. This antibody provides researchers with a reliable tool to further investigate the mechanisms underlying FES-mediated signaling pathways and their implications in disease progression.
Product Name:
FES Rabbit Polyclonal Antibody
SKU:
CAB2578
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 120-420 of human FES (NP_001137256.1).
This gene encodes the human cellular counterpart of a feline sarcoma retrovirus protein with transforming capabilities. The gene product has tyrosine-specific protein kinase activity and that activity is required for maintenance of cellular transformation. Its chromosomal location has linked it to a specific translocation event identified in patients with acute promyelocytic leukemia but it is also involved in normal hematopoiesis as well as growth factor and cytokine receptor signaling. Alternative splicing results in multiple variants encoding different isoforms.
Purification Method:
Affinity purification
Gene ID:
2242
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using FES antibody (CAB2578) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
