The Ferritin Light Chain Polyclonal Antibody is a valuable tool for researchers studying ferritin, a key protein involved in iron storage and homeostasis. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By targeting the ferritin light chain protein, this antibody enables precise detection and analysis in a variety of cell types, making it an essential component for investigations in fields such as metabolism, iron biology, and disease pathology.Ferritin is a critical player in iron metabolism, serving as a storage protein for excess iron and helping to prevent the damaging effects of iron overload.
Dysregulation of ferritin expression and function has been implicated in various diseases, including iron overload disorders, neurodegenerative conditions, and certain types of cancer. By studying ferritin using this polyclonal antibody, researchers can gain insight into the molecular mechanisms underlying these diseases and potentially uncover novel therapeutic targets for intervention.
Product Name:
Ferritin Light Chain Polyclonal Antibody
SKU:
CAB21758
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-175 of human Ferritin Light Chain (NP_000137.2).
cytoplasm, cytosol, extracellular exosome, extracellular region
Calculated MW:
20kDa
Observed MW:
18-20kDa
This gene encodes the light subunit of the ferritin protein. Ferritin is the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in this light chain ferritin gene are associated with several neurodegenerative diseases and hyperferritinemia-cataract syndrome. This gene has multiple pseudogenes.
Purification Method:
Affinity purification
Gene ID:
2512
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates, using Ferritin Light Chain Rabbit pAb (CAB21758) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer:3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
