Ferritin Heavy Chain Monoclonal Antibody (CAB22439)
The Ferritin Heavy Chain Monoclonal Antibody is a valuable tool for researchers studying ferritin, a protein that plays a crucial role in iron storage and metabolism. This antibody, produced through hybridoma technology, is highly specific and sensitive for detection of the ferritin heavy chain in human samples. Validated for use in applications such as Western blot and immunohistochemistry, this antibody enables precise detection and analysis of ferritin heavy chain expression in various cell types.
Ferritin is essential for regulating iron levels in the body and its dysregulation has been implicated in a variety of diseases, including iron-overload disorders and certain cancers. By targeting the ferritin heavy chain protein, researchers can gain insights into the mechanisms underlying these conditions and potentially identify new therapeutic targets. This monoclonal antibody is a valuable tool for advancing research in fields such as iron metabolism, oncology, and molecular biology.
Product Name:
Ferritin Heavy Chain Monoclonal Antibody
SKU:
CAB22439
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 84-183 of human Ferritin Heavy Chain (P02794).
This gene encodes the heavy subunit of ferritin, the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in ferritin proteins are associated with several neurodegenerative diseases. This gene has multiple pseudogenes. Several alternatively spliced transcript variants have been observed, but their biological validity has not been determined.
Purification Method:
Affinity purification
Gene ID:
2495
Clone Number:
ARC2665
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Immunohistochemistry analysis of paraffin-embedded human colon carcinoma using Ferritin Heavy Chain Rabbit mAb (CAB22439) at dilution of 1:100 (40x lens).Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.
