The FERMT2 Polyclonal Antibody (CAB8709) is a crucial tool for researchers studying FERMT2, a protein involved in cell adhesion, signaling, and cytoskeletal organization. The antibody, generated in rabbits, exhibits high specificity and sensitivity towards human samples and is ideal for use in Western blot assays. By binding to the FERMT2 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it essential for studies in cell biology, developmental biology, and cancer research.
FERMT2, also known as kindlin-2, plays a pivotal role in integrin signaling and focal adhesion dynamics, essential processes for cell migration, invasion, and tissue remodeling. Dysregulation of FERMT2 has been implicated in various pathologies, including cancer metastasis and cardiovascular diseases. Investigating the functions and mechanisms of FERMT2 can provide valuable insights into disease progression and potential therapeutic targets in these conditions.
Product Name:
FERMT2 Rabbit Polyclonal Antibody
SKU:
CAB8709
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 380-550 of human FERMT2 (NP_006823.1).
Enables several functions, including actin binding activity; phosphatidylinositol-3,4,5-trisphosphate binding activity; and type I transforming growth factor beta receptor binding activity. Involved in several processes, including cell surface receptor signaling pathway; positive regulation of cell differentiation; and positive regulation of cellular component biogenesis. Acts upstream of or within cell adhesion and protein localization to cell junction. Located in cytosol; focal adhesion; and nucleoplasm. Is extrinsic component of cytoplasmic side of plasma membrane. Part of adherens junction and plasma membrane. Biomarker of acute myeloid leukemia.
Purification Method:
Affinity purification
Gene ID:
10979
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using FERMT2 Rabbit pAb (CAB8709) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
