The FDPS Polyclonal Antibody (CAB5744) is a valuable tool for researchers studying the FDPS gene, which encodes for farnesyl diphosphate synthase, an enzyme involved in the biosynthesis of isoprenoids. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the FDPS protein, this antibody allows for the detection and analysis of FDPS expression in various cell types, making it an essential asset for studies in biochemistry, metabolism, and drug development.FDPS plays a crucial role in the mevalonate pathway, which is essential for the production of cholesterol, steroid hormones, and other molecules vital for cell function.
Dysregulation of FDPS activity has been implicated in a variety of diseases, including cancer, cardiovascular disorders, and metabolic syndromes. Therefore, understanding the function and regulation of FDPS is essential for developing targeted therapies and interventions for these conditions.In summary, the FDPS Polyclonal Antibody (CAB5744) is a reliable tool for researchers investigating the role of FDPS in cellular processes and disease pathogenesis. Its specificity and sensitivity make it a valuable asset for studies aiming to uncover the potential therapeutic implications of targeting FDPS in various pathological conditions.
Product Name:
FDPS Rabbit Polyclonal Antibody
SKU:
CAB5744
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 120-419 of human FPS/FDPS (NP_001995.1).
This gene encodes an enzyme that catalyzes the production of geranyl pyrophosphate and farnesyl pyrophosphate from isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The resulting product, farnesyl pyrophosphate, is a key intermediate in cholesterol and sterol biosynthesis, a substrate for protein farnesylation and geranylgeranylation, and a ligand or agonist for certain hormone receptors and growth receptors. Drugs that inhibit this enzyme prevent the post-translational modifications of small GTPases and have been used to treat diseases related to bone resorption. Multiple pseudogenes have been found on chromosomes 1, 7, 14, 15, 21 and X. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
2224
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using FPS/FDPS Rabbit pAb antibody (CAB5744) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
