FDPS Rabbit Polyclonal Antibody (CAB5744)
- SKU:
- CAB5744
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
Product Name: | FDPS Rabbit Polyclonal Antibody |
SKU: | CAB5744 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 120-419 of human FPS/FDPS (NP_001995.1). |
Sequence: | IGGK YNRG LTVV VAFR ELVE PRKQ DADS LQRA WTVG WCVE LLQA FFLV ADDI MDSS LTRR GQIC WYQK PGVG LDAI NDAN LLEA CIYR LLKL YCRE QPYY LNLI ELFL QSSY QTEI GQTL DLLT APQG NVDL VRFT EKRY KSIV KYKT AFYS FYLP IAAA MYMA GIDG EKEH ANAK KILL EMGE FFQI QDDY LDLF GDPS VTGK IGTD IQDN KCSW LVVQ CLQR ATPE QYQI LKEN YGQK EAEK VARV KALY EELD LPAV FLQY EEDS YSHI MALI EQYA APLP PAVF LGLA RKIY KRRK |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:100 - 1:500 |
Synonyms: | FPS; FPPS; POROK9; FPS/FDPS |
Positive Sample: | THP-1,Mouse liver,Rat liver |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm. |
Calculated MW: | 48kDa |
Observed MW: | 39kDa |
This gene encodes an enzyme that catalyzes the production of geranyl pyrophosphate and farnesyl pyrophosphate from isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The resulting product, farnesyl pyrophosphate, is a key intermediate in cholesterol and sterol biosynthesis, a substrate for protein farnesylation and geranylgeranylation, and a ligand or agonist for certain hormone receptors and growth receptors. Drugs that inhibit this enzyme prevent the post-translational modifications of small GTPases and have been used to treat diseases related to bone resorption. Multiple pseudogenes have been found on chromosomes 1, 7, 14, 15, 21 and X. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 2224 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |