The FDCSP Polyclonal Antibody (PAC019651) is a valuable tool for researchers studying FDCSP, a cell surface molecule with implications in immune regulation and cancer biology. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the FDCSP protein, this antibody enables the detection and analysis of FDCSP expression in various cell types, making it an essential component for studies in immunology and oncology research.
FDCSP, also known as follicular dendritic cell secreted protein, plays a crucial role in immune function by regulating immune responses and supporting tumor progression. Its involvement in immune cell interaction and signaling pathways makes it a promising target for investigating diseases such as cancer and autoimmune disorders. Research on FDCSP is essential for developing targeted therapies that can modulate immune responses and potentially improve outcomes for patients with these conditions.
Antibody Name:
FDCSP Antibody (PACO19651)
Antibody SKU:
PACO19651
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:2000, IHC:1:25-1:100
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human FDCSP
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO19651(FDCSP Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using PACO19651(FDCSP Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
This gene encodes a small secreted protein that is expressed in follicular dendritic cells. This protein specifically binds to activated B cells, and functions as a regulator of antibody responses. It is also thought to contribute to tumor metastases by promoting cancer cell migration and invasion.
Synonyms:
follicular dendritic cell secreted protein
UniProt Protein Function:
FDCSP: Can bind to the surface of B-lymphoma cells, but not T- lymphoma cells, consistent with a function as a secreted mediator acting upon B-cells.Protein type: Secreted, signal peptide; SecretedChromosomal Location of Human Ortholog: 4q13|4q13Cellular Component: extracellular region
UniProt Protein Details:
NCBI Summary:
This gene encodes a small secreted protein that is expressed in follicular dendritic cells. This protein specifically binds to activated B cells, and functions as a regulator of antibody responses. It is also thought to contribute to tumor metastases by promoting cancer cell migration and invasion. [provided by RefSeq, Dec 2011]
