The FCRLB Polyclonal Antibody (PACO09269) is a key tool for researchers studying FCRLB, a member of the Fc receptor-like (FCRL) family of proteins involved in immune regulation. This antibody, generated in rabbits, is highly specific to human samples and is validated for use in Western blot experiments. By targeting the FCRLB protein, this antibody facilitates the detection and analysis of FCRLB expression in various cell types, making it ideal for investigations in immunology and cancer research.
FCRLB, also known as Fc receptor-like-B, functions as a cell surface receptor involved in immune responses and antibody-mediated signaling. Its role in immune modulation suggests its potential as a therapeutic target for diseases such as cancer, autoimmune disorders, and inflammatory conditions. Studies on FCRLB activity are crucial for developing novel treatments that manipulate the immune system to combat these disorders effectively.
Fc receptor-like B;FCRLB;FCRL2;FCRLM2;FCRLY;FLJ31052;FREB-2;FcRY;RP11-474I16.6 ;
UniProt Protein Function:
FCRLB: 5 isoforms of the human protein are produced by alternative splicingProtein type: Secreted, signal peptide; SecretedChromosomal Location of Human Ortholog: 1q23.3Cellular Component: cytoplasm; endoplasmic reticulumBiological Process: negative regulation of immune response
UniProt Protein Details:
NCBI Summary:
FCRL2 belongs to the Fc receptor family. Fc receptors are involved in phagocytosis, antibody-dependent cell cytotoxicity, immediate hypersensitivity, and transcytosis of immunoglobulins via their ability to bind immunoglobulin (Ig) constant regions (Chikaev et al., 2005 [PubMed 15676285]).[supplied by OMIM, Mar 2008]
Fc receptor homolog expressed in B-cells protein 2; FREB-2; Fc receptor-like and mucin-like protein 2; Fc receptor-like protein 2; Fc receptor-related protein Y; FcRY
