The FCRL3 Polyclonal Antibody (CAB10451) is a valuable tool for researchers studying FCRL3, a member of the Fc receptor-like family of proteins known to be involved in immune regulation. This antibody, generated in rabbits, exhibits excellent reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the FCRL3 protein, it enables the detection and analysis of FCRL3 in various cell types, making it ideal for studies in immunology and cancer research.
FCRL3, also known as Fc receptor-like 3, is a key player in immune response modulation, with implications in inflammatory diseases, autoimmune disorders, and cancer. By understanding the function of FCRL3, researchers can gain insights into potential therapeutic strategies for manipulating immune responses in these disease contexts. The FCRL3 Polyclonal Antibody is a valuable tool for investigating the role of FCRL3 in immune regulation and disease pathogenesis.
Product Name:
FCRL3 Rabbit Polyclonal Antibody
SKU:
CAB10451
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 600-720 of human FCRL3 (NP_443171.2).
Cell membrane, Single-pass type I membrane protein.
Calculated MW:
81kDa
Observed MW:
105kDa
This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains immunoreceptor-tyrosine activation motifs and immunoreceptor-tyrosine inhibitory motifs in its cytoplasmic domain and may play a role in regulation of the immune system. Mutations in this gene have been associated with rheumatoid arthritis, autoimmune thyroid disease, and systemic lupus erythematosus. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
115352
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using FCRL3 antibody (CAB10451) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3s.
