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FCHO1 Antibody (PACO57764)

SKU:
PACO57764
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
IHC
IF
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
  • FCHO1 Antibody PACO57764
  • FCHO1 Antibody PACO57764
  • FCHO1 Antibody PACO57764
€359

Description

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FCHO1 Antibody (PACO57764)

The FCHO1 Polyclonal Antibody (PAC05764) is a valuable tool for researchers studying the function of the FCHO1 protein, which plays a role in clathrin-mediated endocytosis. This antibody, raised in rabbits, is highly specific to human samples and has been validated for use in Western blot applications.FCHO1 is a key player in the process of internalizing cell surface receptors, such as growth factor receptors and nutrient transporters, into the cell. Dysregulation of endocytosis has been implicated in various diseases, including cancer and neurodegenerative disorders.

Therefore, studying the function of FCHO1 is essential for understanding these disease processes and developing potential therapeutic interventions.By using the FCHO1 Polyclonal Antibody, researchers can detect and analyze the expression of FCHO1 in different cell types, allowing for insights into its role in endocytosis and its potential implications in various disease states. This antibody is a valuable tool for studies in cell biology, cancer research, and drug development.

Antibody Name:FCHO1 Antibody (PACO57764)
Antibody SKU:PACO57764
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, IHC, IF
Recommended Dilutions:ELISA:1:2000-1:10000, IHC:1:200-1:500, IF:1:50-1:200
Species Reactivity:Human
Immunogen:Recombinant Human F-BAR domain only protein 1 protein (45-180AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageIHC image of PACO57764 diluted at 1:300 and staining in paraffin-embedded human pancreatic cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Product ImageImmunofluorescence staining of MCF-7 cells with PACO57764 at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Product ImageIHC image of PACO57764 diluted at 1:300 and staining in paraffin-embedded human appendix tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Background:Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. May regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors.
Synonyms:F-BAR domain only protein 1, FCHO1, KIAA0290
UniProt Protein Function:Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. May regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors.
UniProt Protein Details:
NCBI Summary:
UniProt Code:O14526
NCBI GenInfo Identifier:20380149
NCBI Gene ID:23149
NCBI Accession:BC028021
UniProt Secondary Accession:O14526,Q05C93, Q8IW22, A6NHE6, A8K5U5, B4E120
UniProt Related Accession:O14526
Molecular Weight:91,013 Da
NCBI Full Name:Homo sapiens FCH domain only 1, mRNA
NCBI Synonym Full Names:FCH domain only 1
NCBI Official Symbol:FCHO1  
NCBI Official Synonym Symbols:
NCBI Protein Information:F-BAR domain only protein 1
UniProt Protein Name:F-BAR domain only protein 1
UniProt Synonym Protein Names:
Protein Family:F-BAR domain only protein
UniProt Gene Name:FCHO1  
UniProt Entry Name:
Secondary Antibody
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)
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