FCGR3A Rabbit Polyclonal Antibody (CAB2552)
- SKU:
- CAB2552
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
Product Name: | FCGR3A Rabbit Polyclonal Antibody |
SKU: | CAB2552 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 150-250 of human FCGR3A (NP_000560.7). |
Sequence: | YFHH NSDF YIPK ATLK DSGS YFCR GLFG SKNV SSET VNIT ITQG LAVS TISS FFPP GYQV SFCL VMVL LFAV DTGL YFSV KTNI RSST RDWK DHKF KWRK D |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | CD16; FCG3; CD16A; FCGR3; IGFR3; IMD20; FCR-10; FCRIII; CD16-II; FCGRIII; FCRIIIA; FcGRIIIA; FCGR3A |
Positive Sample: | K-562,Mouse liver,Mouse testis,Rat lung |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Secreted, Single-pass type I membrane protein. |
Calculated MW: | 29kDa |
Observed MW: | 60kDa |
This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other responses, including antibody dependent cellular mediated cytotoxicity and antibody dependent enhancement of virus infections. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene are associated with immunodeficiency 20, and have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 2214 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |