The FCGR2B Polyclonal Antibody (CAB7554) is a valuable tool for research involving FCGR2B, a cell surface receptor known for its role in immune regulation and antibody-mediated responses. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in a variety of applications, including Western blotting. By targeting the FCGR2B protein, this antibody allows for the detection and analysis of FCGR2B expression in different cell types, making it an ideal choice for studies in immunology and cancer research.FCGR2B, also known as CD32, is a key player in the negative regulation of immune responses by modulating the activation of immune cells and controlling the intensity of immune reactions.
Its involvement in immune signaling pathways makes it a promising target for research on autoimmune diseases, inflammation, and cancer. By investigating the function and expression of FCGR2B, researchers can gain valuable insights into the mechanisms underlying immune dysregulation and potentially identify new therapeutic strategies for treating related conditions.
Product Name:
FCGR2B Rabbit Polyclonal Antibody
SKU:
CAB7554
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 241-310 of human FCGR2B (NP_003992.3).
Cell membrane, Single-pass type I membrane protein.
Calculated MW:
34kDa
Observed MW:
40kDa
The protein encoded by this gene is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations in this gene may increase susceptibilty to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
2213
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of human placenta, using FCGR2B antibody (CAB7554) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
