The FCGR2B Polyclonal Antibody (CAB12553) is a valuable tool for researchers studying FCGR2B, a cell surface receptor known to play a crucial role in immune regulation. This antibody, generated in rabbits, exhibits high reactivity towards human samples and has been validated for use in Western blot applications. By specifically binding to the FCGR2B protein, this antibody enables accurate detection and analysis in various cell types, making it ideal for investigations in immunology and cancer research.FCGR2B, also referred to as CD32B, is a key player in immune response modulation, exerting its effects through inhibitory signaling pathways.
Its involvement in regulating immune activation and antibody-mediated responses highlights its importance in diseases such as autoimmune disorders, inflammation, and cancer. Studying the function of FCGR2B is crucial for gaining insights into immune dysregulation and devising targeted therapies to manipulate these pathways for therapeutic purposes. Overall, the FCGR2B Polyclonal Antibody (CAB12553) serves as a reliable tool for researchers aiming to explore the intricate role of FCGR2B in immune regulation and its implications in various disease contexts.
Product Name:
FCGR2B Rabbit Polyclonal Antibody
SKU:
CAB12553
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 43-217 of human FCGR2B (NP_003992.3).
Cell membrane, Single-pass type I membrane protein.
Calculated MW:
34kDa
Observed MW:
40kDa
The protein encoded by this gene is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations in this gene may increase susceptibilty to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
2213
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using FCGR2B Rabbit pAb (CAB12553) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
