FBXW8 Rabbit Polyclonal Antibody (CAB18122)
- SKU:
- CAB18122
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
Product Name: | FBXW8 Rabbit Polyclonal Antibody |
SKU: | CAB18122 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 500-598 of human FBXW8 (NP_699179.2). |
Sequence: | WDYR MNQK LWEV YSGH PVQH ISFS SHSL ITAN VPYQ TVMR NADL DSFT THRR HRGL IRAY EFAV DQLA FQSP LPVC RSSC DAMA THYY DLAL AFPY NHV |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200 |
Synonyms: | FBW6; FBW8; FBX29; FBXW6; FBXO29; FBXW8 |
Positive Sample: | U-87MG,A-549,A-431,Rat lung,Rat heart |
Cellular Localization: | cytosol, Golgi apparatus, perinuclear region of cytoplasm |
Calculated MW: | 67kDa |
Observed MW: | 67kDa |
This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains a WD-40 domain, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.
Purification Method: | Affinity purification |
Gene ID: | 26259 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |