FBXW5 Rabbit Polyclonal Antibody (CAB9345)
- SKU:
- CAB9345
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Signal Transduction
Description
Product Name: | FBXW5 Rabbit Polyclonal Antibody |
SKU: | CAB9345 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 184-566 of human FBXW5 (NP_061871.1). |
Sequence: | VRNK PYDV FGCW LTET SLIS GNLH RIGD ITSC SVLW LNNA FQDV ESEN VNVV KRLF KIQN LNAS TVRT VMVA DCSR FDSP DLLL EAGD PATS PCRI FDLG SDNE EVVA GPAP AHAK EGLR HFLD RVLE GRAQ PQLS ERML ETKV AELL AQGH TKPP ERSA TGAK SKYL IFTT GCLT YSPH QIGI KQIL PHQM TTAG PVLG EGRG SDAF FDAL DHVI DIHG HIIG MGLS PDNR YLYV NSRA WPNG AVVA DPMQ PPPI AEEI DLLV FDLK TMRE VRRA LRAH RAYT PNDE CFFI FLDV SRDF VASG AEDR HGYI WDRH YNIC LARL RHED VVNS VVFS PQEQ ELLL TASD DATI KAWR SPRT MRVL QAPR PRPR TFFS WLAS QRR |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:200 - 1:1000 |
Synonyms: | Fbw5; FBXW5 |
Positive Sample: | A-549 |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm. |
Calculated MW: | 64kDa |
Observed MW: | 72kDa |
This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains WD-40 domains, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene, however, they were found to be nonsense-mediated mRNA decay (NMD) candidates, hence not represented.
Purification Method: | Affinity purification |
Gene ID: | 54461 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |