FBXW4 Rabbit Polyclonal Antibody (CAB8149)
- SKU:
- CAB8149
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Signal Transduction
Description
Product Name: | FBXW4 Rabbit Polyclonal Antibody |
SKU: | CAB8149 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 143-412 of human FBXW4 (NP_071322.1). |
Sequence: | QFRP DGAS LNRR PLGV FAGH DEDV CHFV LANS HIVS AGGD GKIG IHKI HSTF TVKY SAHE QEVN CVDC KGGI IVSG SRDR TAKV WPLA SGRL GQCL HTIQ TEDR VWSI AISP LLSS FVTG TACC GHFS PLRI WDLN SGQL MTHL GSDF PPGA GVLD VMYE SPFT LLSC GYDT YVRY WDLR TSVR KCVM EWEE PHDS TLYC LQTD GNHL LATG SSYY GVVR LWDR RQRA CLHA FPLT STPL SSPV YCLR LTTK HLYA ALSY NLHV LDFQ NP |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | DAC; FBW4; FBWD4; SHFM3; SHSF3; FBXW4 |
Positive Sample: | Mouse brain |
Conjugate: | Unconjugated |
Cellular Localization: | cytosol |
Calculated MW: | 46kDa |
Observed MW: | 46kDa |
This gene is a member of the F-box/WD-40 gene family, which recruit specific target proteins through their WD-40 protein-protein binding domains for ubiquitin mediated degradation. In mouse, a highly similar protein is thought to be responsible for maintaining the apical ectodermal ridge of developing limb buds; disruption of the mouse gene results in the absence of central digits, underdeveloped or absent metacarpal/metatarsal bones and syndactyly. This phenotype is remarkably similar to split hand-split foot malformation in humans, a clinically heterogeneous condition with a variety of modes of transmission. An autosomal recessive form has been mapped to the chromosomal region where this gene is located, and complex rearrangements involving duplications of this gene and others have been associated with the condition. A pseudogene of this locus has been mapped to one of the introns of the BCR gene on chromosome 22.
Purification Method: | Affinity purification |
Gene ID: | 6468 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |